Research / Publications

The following list provides references to selected research articles by collaborators of Evaluation Software Development (ESD) containing information on the development process, the adaptation, improvements and the use of the Computer-based Health Evaluation System (CHES).

  • Evaluation of Noncompletion Bias and Long-Term Adherence in a 10-Year Patient-Reported Outcome Monitoring Program in Clinical Routine. Gamper EM, Nerich V, Sztankay M, Martini C, Giesinger JM, Scarpa L, Buxbaum S, Jeller M,Holzner B, Virgolini I.Value Health. 2017 Apr;20(4):610-617

  • International Psychometric Validation of an EORTC Quality of Life Module Measuring Cancer Related Fatigue (EORTC QLQ-FA12). Weis J, Tomaszewski KA, Hammerlid E, Ignacio Arraras J, Conroy T, Lanceley A, Schmidt H, Wirtz M, Singer S, Pinto M, Alm El-Din M, Compter I,Holzner B, Hofmeister D, Chie WC, Czeladzki M, Harle A, Jones L, Ritter S, Flechtner HH, Bottomley A; EORTC Quality of Life Group. J Natl Cancer Inst. 2017 May 1;109(5).

  • Can we use gonadotropin plasma concentration as surrogate marker for BMI-related incomplete estrogen suppression in breast cancer patients receiving anastrozole? Oberguggenberger A, Meraner V, Sztankay M, Beer B, Weigel G, Oberacher H, Kemmler G, Czech T,Holzner B, Wildt L, Sperner-Unterweger B, Daniaux M, Hubalek M. BMC Cancer. 2017 Mar 28;17(1):226

  • Usage patterns of internet and computer games : Results of an observational study of Tyrolean adolescents. Riedl D, Stöckl A, Nussbaumer C,Rumpold G, Sevecke K, Fuchs M. Neuropsychiatr. 2016 Dec;30(4):181-190. Epub 2016

  • Focusing on Core Patient-Reported Outcomes in Cancer Clinical Trials-Letter. Groenvold M, Aaronson NK, Darlington AE, Fitzsimmons D, Greimel E,Holzner B, Reijneveld JC, Tomaszewski KA, Verdonck-de Leeuw I, van de Poll-Franse L; EORTC Quality of Life Group. Clin Cancer Res. 2016 Nov 15;22(22):5617

  • Order of Presentation of Dimensions Does Not Systematically Bias Utility Weights from a Discrete Choice Experiment. Norman R, Kemmler G, Viney R, Pickard AS, Gamper E,Holzner B, Nerich V, King M.Value Health. 2016 Dec;19(8):1033-1038.

  • The use of EORTC measures in daily clinical practice-A synopsis of a newly developed manual. Wintner LM, Sztankay M, Aaronson N, Bottomley A, Giesinger JM, Groenvold M, Petersen MA, van de Poll-Franse L, Velikova G, Verdonck-de Leeuw I,Holzner B; EORTC Quality of Life Group. Eur J Cancer. 2016 Nov;68:73-81.

  • Systematic review reveals lack of quality in reporting health-related quality of life in patients with gastroenteropancreatic neuroendocrine tumours. Martini C, Gamper EM, Wintner L, Nilica B, Sperner-Unterweger B,Holzner B, Virgolini I. Health Qual Life Outcomes. 2016 Sep 10;14(1):127.

  • Cost-utility analyses of drug therapies in breast cancer: a systematic review. Nerich V, Saing S, Gamper EM, Kemmler G, Daval F, Pivot X,Holzner B. Breast Cancer Res Treat. 2016 Oct;159(3):407-24.

  • Cancer patients' understanding of longitudinal EORTC QLQ-C30 scores presented as bar charts. Loth FL,Holzner B, Sztankay M, Bliem HR, Raoufi S, Rumpold G, Giesinger JM. Patient Educ Couns. 2016 Dec;99(12):2012-2017. doi: 10.1016/j.pec.2016.08.004. Epub 2016 Aug 2.

  • Thresholds for clinical importance for four key domains of the EORTC QLQ-C30: physical functioning, emotional functioning, fatigue and pain. Giesinger JM, Kuijpers W, Young T, Tomaszewski KA, Friend E, Zabernigg A, Holzner B, Aaronson NK. Health Qual Life Outcomes. 2016 Jun 7;14:87.
  • Development of an item bank for the EORTC Role Functioning Computer Adaptive Test (EORTC RF-CAT). Gamper EM, Petersen MA, Aaronson N, Costantini A, Giesinger JM, Holzner B, Kemmler G, Oberguggenberger A, Singer S, Young T, Groenvold M; EORTC Quality of Life Group.Health Qual Life Outcomes. 2016 May 6;14:72.
  • An emotional functioning item bank of 24 items for computerized adaptive testing (CAT) was established. Petersen MA, Gamper EM, Costantini A, Giesinger JM, Holzner B, Johnson C, Sztankay M, Young T, Groenvold M; EORTC Quality of Life Group.J Clin Epidemiol. 2016 Feb;70:90-100.
  • Patients' and health professionals' understanding of and preferences for graphical presentation styles for individual-level EORTC QLQ-C30 scores. Kuijpers W, Giesinger JM, Zabernigg A, Young T, Friend E, Tomaszewska IM, Aaronson NK, Holzner B.Qual Life Res. 2016 Mar;25(3):595-604
  • An emotional functioning item bank of 24 items for computerized adaptive testing (CAT) was established. Petersen MA, Gamper EM, Costantini A, Giesinger JM, Holzner B, Johnson C, Sztankay M, Young T, Groenvold M; EORTC Quality of Life Group.J Clin Epidemiol. 2016 Feb;70:90-100.

  • Patients' and health professionals' understanding of and preferences for graphical presentation styles for individual-level EORTC QLQ-C30 scores.Kuijpers W, Giesinger JM, Zabernigg A, Young T, Friend E, Tomaszewska IM, Aaronson NK, Holzner B. Qual Life Res. 2016 Mar;25(3):595-604.
  • Replication and validation of higher order models demonstrated that a summary score for the EORTC QLQ-C30 is robust.Giesinger JM, Kieffer JM, Fayers PM, Groenvold M, Petersen MA, Scott NW, Sprangers MA, Velikova G, Aaronson NK; EORTC Quality of Life Group.J Clin Epidemiol. 2016 Jan;69:79-88
  • Quality of life across chemotherapy lines in patients with advanced colorectal cancer: a prospective single-center observational study. Mayrbäurl B, Giesinger JM, Burgstaller S, Piringer G, Holzner B, Thaler J. Support Care Cancer. 2016 Feb;24(2):667-74.
  • Evaluation of electronic patient-reported outcome assessment with cancer patients in the hospital and at home. Wintner LM, Giesinger JM, Zabernigg A, Rumpold G, Sztankay M, Oberguggenberger AS, Gamper EM, Holzner B. BMC Med Inform Decis Mak. 2015 Dec 23;15:110.

  • Development Of A Web-Based Quality Of Life Portal For Breast Cancer Patients. Loth FL, Sztankay M, Giesinger JM, Rumpold G, Holzner B. Value Health. 2015 Nov;18(7):A473.

  • Patients' Preferences Regarding The Setting Of Electronic Patient-Reported Outcome Assessments. Holzner B, Giesinger JM, Zabernigg A, Loth FL, Rumpold G, Wintner LM.Value Health. 2015 Nov;18(7):A473.

  • Development of an item list to assess the forgotten joint concept in shoulder patients. Giesinger JM, Kesterke N, Hamilton DF, Holzner B, Jost B, Giesinger K.BMC Musculoskelet Disord. 2015 Mar 24;16:67.

  • Development of a lack of appetite item bank for computer-adaptive testing (CAT). Thamsborg LH, Petersen MA, Aaronson NK, Chie WC, Costantini A, Holzner B, Verdonck-de Leeuw IM, Young T, Groenvold M; EORTC Quality of Life Group. Support Care Cancer. 2015 Jun;23(6):1541-8
  • Persistent quality of life impairments in differentiated thyroid cancer patients: results from a monitoring programme. Gamper EM, Wintner LM, Rodrigues M, Buxbaum S, Nilica B, Singer S, Giesinger JM, Holzner B, Virgolini I. Eur J Nucl Med Mol Imaging. 2015 Jul;42(8):1179-8
  • Development of an item list to assess the forgotten joint concept in shoulder patients. Giesinger JM, Kesterke N, Hamilton DF, Holzner B, Jost B, Giesinger K. BMC Musculoskelet Disord. 2015 Mar 24;16:67
  • Quality of life across chemotherapy lines in patients with advanced colorectal cancer: a prospective single-center observational study. Mayrbäurl B, Giesinger JM, Burgstaller S, Piringer G, Holzner B, Thaler J. Support Care Cancer. 2015
  • Assessing quality of life on the day of chemotherapy administration underestimates patients' true symptom burden.Giesinger JM, Wintner LM, Zabernigg A, Gamper EM, Oberguggenberger AS, Sztankay MJ, Kemmler G, Holzner B. BMC Cancer. 2014 Oct 10;14:758
  • Getting the Whole Picture: Adding Patient-reported Outcomes to Adjuvant Endocrine Treatment Evaluation in Premenopausal Breast Cancer Patients. Oberguggenberger A, Goebel G, Beer B, Oberacher H, Meraner V, Sztankay M, Sperner-Unterweger B, Zeimet AG, Marth C, Hubalek M, Holzner B. Breast J. 2014
  • Recruiting long-term survivors of European Organisation for Research and Treatment of Cancer phase III clinical trials into quality of life studies: challenges and opportunities. van Leeuwen M, Efficace F, Fosså SD, Bolla M, De Giorgi U, de Wit R, Holzner B, van de Poll-Franse LV, van Poppel H, White J, Collette L, Osanto S, Aaronson NK; European Organisation for Research and Treatment of Cancer Quality of Life Group; Genito-Urinary Cancers Group; Radiation Oncology Group. Eur J Cancer. 2014 Jul;50(11):1957-63.
  • Danish population-based reference data for the EORTC QLQ-C30: associations with gender, age and morbidity. Juul T, Petersen MA, Holzner B, Laurberg S, Christensen P, Grønvold M. Qual Life Res. 2014 Mar 28.
  • Does obesity interfere with anastrozole treatment? Positive association between body mass index and anastrozole plasma levels. Hubalek M, Oberguggenberger A, Beer B, Meraner V, Sztankay M, Oberacher H, Schubert B, Wildt L, Seeber B, Giesinger J, Kemmler G, Holzner B, Sperner-Unterweger B. Clin Breast Cancer. 2014 Aug;14(4):291-6.
  • A single-arm phase II Austrian/German multicenter trial on continuous daily sunitinib in primary glioblastoma at first recurrence (SURGE 01-07). Hutterer M, Nowosielski M, Haybaeck J, Embacher S, Stockhammer F, Gotwald T, Holzner B, Capper D, Preusser M, Marosi C, Oberndorfer S, Moik M, Buchroithner J, Seiz M, Tuettenberg J, Herrlinger U, Wick A, Vajkoczy P, Stockhammer G. Neuro Oncol. 2014 Jan;16(1):92-102.
  • Comparative responsiveness of outcome measures for total knee arthroplasty. Giesinger K, Hamilton DF, Jost B, Holzner B, Giesinger JM. Osteoarthritis Cartilage. 2014 Feb;22(2):184-9.
  • Patient-reported outcome reference values for patients after kidney transplantation. Kumnig M, Rumpold G, Höfer S, König P, Holzner B, Giesinger J, Gamper EM, Zabernigg A, Hoflehner A. Wien Klin Wochenschr. 2014 Jan;126(1-2):15-22.
  • The EORTC emotional functioning computerized adaptive test: phases I-III of a cross-cultural item bank development. Gamper EM, Groenvold M, Petersen MA, Young T, Costantini A, Aaronson N, Giesinger JM, Meraner V, Kemmler G, Holzner B; EORTC Quality of Life Group. Psychooncology. 2014 Apr;23(4):397-403.
  • Distress in primary caregivers and patients listed for liver transplantation. Malik P, Kohl C, Holzner B, Kemmler G, Graziadei I, Vogel W, Sperner-Unterweger B. Psychiatry Res. 2014 Jan 30;215(1):159-62.
  • Quality of life during chemotherapy in lung cancer patients: results across different treatment lines. Wintner LM, Giesinger JM, Zabernigg A, Sztankay M, Meraner V, Pall G, Hilbe W, Holzner B. Br J Cancer. 2013 Oct 29;109(9):2301-8.
  • Psychiatric consultation-liaison interventions: recollection, perception and outcome. Laner B, Staufer C, Giesinger JM, Gross R, Kohl C, Malik P, Holzner B, Sperner-Unterweger B. J Psychosom Res. 2013 Aug;75(2):184-6.
  • Psychometric evaluation of the EORTC computerized adaptive test (CAT) fatigue item pool. Petersen MA, Giesinger JM, Holzner B, Arraras JI, Conroy T, Gamper EM, King MT, Verdonck-de Leeuw IM, Young T, Groenvold M. Qual Life Res. 2013 Feb 28.
  • The EORTC computer-adaptive tests measuring physical functioning and fatigue exhibited high levels of measurement precision and efficiency. Petersen MA, Aaronson NK, Arraras JI, Chie WC, Conroy T, Costantini A, Giesinger JM, Holzner B, King MT, Singer S, Velikova G, Verdonck-de Leeuw IM, Young T, Groenvold M; EORTC Quality of Life Group. J Clin Epidemiol. 2013 Mar;66(3):330-9. doi: 10.1016/j.jclinepi.2012.09.010.
  • Development of a computer-adaptive version of the forgotten joint score. Giesinger JM, Kuster MS, Holzner B, Giesinger K., J Arthroplasty. 2013 Mar;28(3):418-22. doi: 10.1016/j.arth.2012.08.026. Epub 2012 Dec 5.
  • The Computer-based Health Evaluation Software (CHES): a software for electronic patient-reported outcome monitoring. Holzner B, Giesinger JM, Pinggera J, Zugal S, Schöpf F, Oberguggenberger AS, Gamper EM, Zabernigg A, Weber B, Rumpold G. BMC Med Inform Decis Mak. 2012;12:126. doi: 10.1186/1472-6947-12-126.
  • Quality of life across chemotherapy lines in patients with cancers of the pancreas and biliary tract. Zabernigg A, Giesinger JM, Pall G, Gamper EM, Gattringer K, Wintner LM, Sztankay MJ, Holzner B. BMC Cancer. 2012 Sep 6;12:390. doi: 10.1186/1471-2407-12-390.
  • Coming to your senses: detecting taste and smell alterations in chemotherapy patients. A systematic review. Gamper EM, Zabernigg A, Wintner LM, Giesinger JM, Oberguggenberger A, Kemmler G, Sperner-Unterweger B, Holzner B. J Pain Symptom Manage. 2012 Dec;44(6):880-95. doi: 10.1016/j.jpainsymman.2011.11.011. Epub 2012 Aug 24.
  • The benefits of using patient-reported outcomes in cancer treatment: an overview. Wintner LM, Giesinger JM, Kemmler G, Sztankay M, Oberguggenberger A, Gamper EM, Sperner-Unterweger B, Holzner B. Wien Klin Wochenschr. 2012 May;124(9-10):293-303. doi: 10.1007/s00508-012-0168-3. Epub 2012 Apr 27.
  • Monitoring physical and psychosocial symptom trajectories in ovarian cancer patients receiving chemotherapy. Meraner V, Gamper EM, Grahmann A, Giesinger JM, Wiesbauer P, Sztankay M, Zeimet AG, Sperner-Unterweger B, Holzner B. BMC Cancer. 2012 Feb 28;12:77. doi: 10.1186/1471-2407-12-77.
  • Chemotherapy line-associated differences in quality of life in patients with advanced cancer. Mayrbäurl B, Wintner LM, Giesinger JM, Himmelfreundpointner T, Burgstaller S, Holzner B, Thaler J. Support Care Cancer. 2012 Oct;20(10):2399-405. doi: 10.1007/s00520-011-1355-x. Epub 2011 Dec 29.
  • Quality of life trajectory in patients with advanced cancer during the last year of life. Giesinger JM, Wintner LM, Oberguggenberger AS, Gamper EM, Fiegl M, Denz H, Kemmler G, Zabernigg A, Holzner B. J Palliat Med. 2011 Aug;14(8):904-12. doi: 10.1089/jpm.2011.0086. Epub 2011 Jun 28.
  • Cross-cultural development of an item list for computer-adaptive testing of fatigue in oncological patients. Giesinger JM, Aa Petersen M, Groenvold M, Aaronson NK, Arraras JI, Conroy T, Gamper EM, Kemmler G, King MT, Oberguggenberger AS, Velikova G, Young T, Holzner B; European Organisation for Research and Treatment of Cancer Quality of Life Group (EORTC-QLG). Health Qual Life Outcomes. 2011 Mar 29;9:19. doi: 10.1186/1477-7525-9-19.
  • Patient reported outcome monitoring using a tablet PC is suitable for measuring quality of life in patients with gliomas. Holzner B, Schauer-Maurer G, Stockhammer G, Muigg A, Hutterer M, Giesinger J. Wien Med Wochenschr. 2011 Jan;161(1-2):6-12. doi: 10.1007/s10354-011-0872-z.
  • Development of computerized adaptive testing (CAT) for the EORTC QLQ-C30 physical functioning dimension. Petersen MA, Groenvold M, Aaronson NK, Chie WC, Conroy T, Costantini A, Fayers P, Helbostad J, Holzner B, Kaasa S, Singer S, Velikova G, Young T. Qual Life Res. 2011 May;20(4):479-90. doi: 10.1007/s11136-010-9770-x. Epub 2010 Oct 23.
  • Development of computerised adaptive testing (CAT) for the EORTC QLQ-C30 dimensions - general approach and initial results for physical functioning. Petersen MA, Groenvold M, Aaronson NK, Chie WC, Conroy T, Costantini A, Fayers P, Helbostad J, Holzner B, Kaasa S, Singer S, Velikova G, Young T; EORTC Quality of Life Group. Eur J Cancer. 2010 May;46(8):1352-8. doi: 10.1016/j.ejca.2010.02.011. Epub 2010 Mar 16.
  • Taste alterations in cancer patients receiving chemotherapy: a neglected side effect? Zabernigg A, Gamper EM, Giesinger JM, Rumpold G, Kemmler G, Gattringer K, Sperner-Unterweger B, Holzner B. Oncologist. 2010;15(8):913-20. Epub 2010 Jul 28.
  • Implementation of computer-based quality-of-life monitoring in brain tumor outpatients in routine clinical practice. Erharter A, Giesinger J, Kemmler G, Schauer-Maurer G, Stockhammer G, Muigg A, Hutterer M, Rumpold G, Sperner-Unterweger B, Holzner B. J Pain Symptom Manage. 2010 Feb;39(2):219-29.0 Mar 15.
  • Do neurooncological patients and their significant others agree on quality of life ratings? Giesinger JM, Golser M, Erharter A, Kemmler G, Schauer-Maurer G, Stockhammer G, Muigg A, Hutterer M, Rumpold G, Holzner B. Health Qual Life Outcomes. 2009 Oct 9;7:87.
  • A new approach to combining clinical relevance and statistical significance for evaluation of quality of life changes in the individual patient. Kemmler G, Zabernigg A, Gattringer K, Rumpold G, Giesinger J, Sperner-Unterweger B, Holzner B. J Clin Epidemiol. 2010 Feb;63(2):171-9. Epub 2009 Jul 16.
  • Are gender-associated differences in quality of life in colorectal cancer patients disease-specific? Giesinger J, Kemmler G, Mueller V, Zabernigg A, Mayrbaeurl B, Thaler J, Ofner D, Pegger C, Rumpold G, Weber B, Sperner-Unterweger B, Holzner B. Qual Life Res. 2009 Jun;18(5):547-55. Epub 2009 Apr 1.
  • Development of a screening tool for the identification of psychooncological treatment need in breast cancer patients. Meraner V, Giesinger J, Kemmler G, Taucher S, Hubalek M, Weber B, Rumpold G, Sperner-Unterweger B, Holzner B. Psychooncology. 2009 Sep;18(9):974-83.
  • Towards the Implementation of Quality of Life Monitoring in Daily Clinical Routine: Methodological Issues and Clinical Implication. Giesinger J, Kemmler G, Meraner V, Gamper EM, Oberguggenberger A, Sperner-Unterweger B, Holzner B. Breast Care (Basel). 2009;4(3):148-154. Epub 2009 Jun 26.